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Melbourne Brain Genome Project
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Description
Performs Fisher's exact test for testing the null of independence of rows and columns in a contingency table with fixed marginals.
Usage
fisher.test(x, y = NULL, workspace = 200000, hybrid = FALSE,
or = 1, alternative = "two.sided", conf.level = 0.95)
Arguments
x |
either a two-dimensional contingency table in matrix form, or a factor object. |
y |
a factor object; ignored if x is a matrix. |
workspace |
an integer specifying the size of the workspace used in the network algorithm. |
hybrid |
a logical indicating whether the exact probabilities (default) or a hybrid approximation thereof should be computed. In the hybrid case, asymptotic chi-squared probabilities are only used provided that the ``Cochran'' conditions are satisfied. |
or |
the hypothesized odds ratio. Only used in the 2 by 2 case. |
alternative |
indicates the alternative hypothesis and must be one of "two.sided", "greater" or "less". You can specify just the initial letter. Only used in the 2 by 2 case. |
conf.level |
confidence level for the returned confidence interval. Only used in the 2 by 2 case. |
Details
If x is a matrix, it is taken as a two-dimensional contingency table, and hence its entries should be nonnegative integers. Otherwise, both x and y must be vectors of the same length. Incomplete cases are removed, the vectors are coerced into factor objects, and the contingency table is computed from these.
In the one-sided 2 by 2 cases, p-values are obtained directly using the hypergeometric distribution. Otherwise, computations are based on a C version of the FORTRAN subroutine FEXACT which implements the network developed by Mehta and Patel (1986) and improved by Clarkson, Fan & Joe (1993). The FORTRAN code can be obtained from http://www.netlib.org/toms/643.
In the 2 by 2 case, the null of conditional independence is equivalent to the hypothesis that the odds ratio equals one. Exact inference can be based on observing that in general, given all marginal totals fixed, the first element of the contingency table has a non-central hypergeometric distribution with non-centrality parameter given by the odds ratio (Fisher, 1935).
Value
A list with class "htest" containing the following components:
p.value |
the p-value of the test. |
conf.int |
a confidence interval for the odds ratio. Only present in the 2 by 2 case. |
estimate |
an estimate of the odds ratio. Note that the conditional Maximum Likelihood Estimate (MLE) rather than the unconditional MLE (the sample odds ratio) is used. Only present in the 2 by 2 case. |
null.value |
the odds ratio under the null, or. Only present in the 2 by 2 case. |
alternative |
a character string describing the alternative hypothesis. |
method |
the character string "Fisher's Exact Test for Count Data". |
data.name |
a character string giving the names of the data. |
References
Alan Agresti (1990). Categorical data analysis. New York: Wiley. Pages 59–66.
Fisher, R. A. (1935). The logic of inductive inference. Journal of the Royal Statistical Society Series A 98, 39–54.
Fisher, R. A. (1962). Confidence limits for a cross-product ratio. Australian Journal of Statistics 4, 41.
Cyrus R. Mehta & Nitin R. Patel (1986). Algorithm 643. FEXACT: A Fortran subroutine for Fisher's exact test on unordered r*c contingency tables. ACM Transactions on Mathematical Software, 12, 154–161.
Douglas B. Clarkson, Yuan-an Fan & Harry Joe (1993). A Remark on Algorithm 643: FEXACT: An Algorithm for Performing Fisher's Exact Test in r x c Contingency Tables. ACM Transactions on Mathematical Software, 19, 484–488.
Benjamini and Hochberg Procedure.
This is based on the paper by Benjamini Y. and Hochberg Y. (1995). Controlling the False Discovery Rate : a Practical and Powerful Approach to Multiple Testing. J.R.Statist.Soc. B 57, No. 1, pp. 289-300.
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