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			Melbourne Brain Genome Project

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This form employs the comparative count display software from NCBI, which performs a key-by-key comparison of two key-count distributions by generating a probability that the frequency of any key in the distribution differs by more than a given fold factor from the other distribution. Thus for two SAGE libraries, it performs a differential, tag-by-tag count comparison. Libraries may have unequal numbers of total tags. The software uses a key mapping file where the first column contains the key. If the key is *not* in this file, then it will not be compared.

The statistic is described in Lash et al. Genome Res. 2000 Jul;10(7):1051-60 ([PubMed]) and at NCBI.

Input:
Two optional library files, each in one of the following formats:
a) single column list of keys (tags) in library, or
b) two column list of keys (tags) and key count (tab delimited). For example:

AAAAAAAAAA 174
AAAAAAAAAG 1
AAAAAAAAAT 1
AAAAAAAATA 2

Output:
A four column table, with optional header lines. Columns are, from left to right, p-value, key freq or count in library 'A', key freq or count in library 'B', key. Additional columns depend upon columns in key mapping file.