Identification of biological processes regulated by the transcription factor RUNX1: implication for leukemia and thrombocytopenia development
Table I
| Acc | UGCluster | Name | Symbol | FPD | FPD M | FPD t | CBF | CBF M | CBF t | TELRUNX1 | TELRUNX1 M | TELRUNX1 t | Refseq | CUREOS | Human Gene ID | mouse Affymetrix probes | E8.5 | M 8.5 | t 8.5 | E12 | M 12 | t 12 | mouse Unigene | Mouse Gene Symbol |
| AA001219 | Hs.527973 | Suppressor of cytokine signaling 3 | SOCS3 | 0 | -0.02 | -0.4 | 0 | 0.01 | 0.2 | 0 | -0.1 | -1.4 | NM_003955 | 1 | 9021 | 1416576_at | -1 | -0.3 | -1.193 | 0 | 2.74E-01 | 1.09E+00 | Mm.3468 | Socs3 |
| 1455899_x_at | -1.715 | -2.492 | -2.25E-01 | -3.28E-01 | Mm.3468 | Socs3 | ||||||||||||||||||
| 1456212_x_at | -1.397 | -1.784 | -1.10E-01 | -1.41E-01 | Mm.3468 | Socs3 | ||||||||||||||||||
| AA001376 | Hs.157883 | Zinc finger protein 187 | ZNF187 | 0 | 0.04 | 0.5 | 0 | 0.06 | 0.9 | 0 | 0 | 0 | NM_152736 | ND | 7741 | 1457285_at | 0 | 0.021 | 0.037 | 0 | 4.06E-01 | 7.16E-01 | Mm.235360 | |
| AA001403 | Hs.132642 | "Zinc metallopeptidase (STE24 homolog, yeast)" | ZMPSTE24 | 0 | 0.09 | 1.3 | 0 | 0.06 | 1.4 | 1 | 0.21 | 3.2 | NM_005857 | 0 | 10269 | 1427923_at | 0 | 0.088 | 0.282 | 0 | 5.09E-01 | 1.63E+00 | Mm.34399 | Zmpste24 |
| AA001432 | Hs.436367 | "Laminin, alpha 3" | LAMA3 | 0 | 0.16 | 1.4 | 0 | -0.02 | -0.4 | 0 | -0.09 | -1.4 | NM_000227 | 0 | 3909 | 1427512_a_at | 0 | 0.23 | 0.854 | 0 | -1.76E-01 | -6.53E-01 | Mm.42012 | Lama3 |
| 1444860_at | -0.077 | -0.367 | 1.40E-02 | 6.65E-02 | Mm.42012 | Lama3 | ||||||||||||||||||
| AA001444 | Hs.526754 | "Meis1, myeloid ecotropic viral integration site 1 homolog (mouse)" | MEIS1 | 0 | 0.13 | 1.1 | 1 | 0.2 | 3.9 | 1 | 0.18 | 2.6 | NM_002398 | 1 | 4211 | Data not found | ND | ND | ||||||
| AA001449 | Hs.371249 | "Pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1)" | PTN | 0 | -0.03 | -0.3 | 0 | 0.08 | 0.8 | 0 | 0.14 | 0.9 | NM_002825 | 1 | 5764 | 1416211_a_at | 0 | 1.168 | 0.926 | 0 | 3.72E-01 | 2.95E-01 | Mm.279690 | Ptn |
| 1443173_at | 0.094 | 0.244 | 3.27E-01 | 8.53E-01 | Mm.279690 | Ptn | ||||||||||||||||||
| 1443809_at | -0.057 | -0.316 | 2.63E-02 | 1.47E-01 | Mm.279690 | Ptn | ||||||||||||||||||
| 1448254_at | 2.288 | 1.509 | 2.09E-01 | 1.38E-01 | Mm.279690 | Ptn | ||||||||||||||||||
| AA001449 | Hs.371249 | "Pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1)" | PTN | 0 | 0.18 | 2.4 | 0 | 0.01 | 0.1 | 0 | -0.09 | -0.9 | NM_002825 | 1 | 5764 | 1416211_a_at | 0 | 1.168 | 0.926 | 0 | 3.72E-01 | 2.95E-01 | Mm.279690 | Ptn |
| 1443173_at | 0.094 | 0.244 | 3.27E-01 | 8.53E-01 | Mm.279690 | Ptn | ||||||||||||||||||
| 1443809_at | -0.057 | -0.316 | 2.63E-02 | 1.47E-01 | Mm.279690 | Ptn | ||||||||||||||||||
| 1448254_at | 2.288 | 1.509 | 2.09E-01 | 1.38E-01 | Mm.279690 | Ptn | ||||||||||||||||||
| AA001614 | Data not found | 0 | 0.22 | 2.7 | 0 | 0.04 | 0.6 | 0 | 0.21 | 2 | ND | Data not found | ||||||||||||
| AA001745 | Hs.445803 | DC2 protein | DC2 | -1 | -0.28 | -5.4 | 0 | 0.06 | 2.1 | 0 | 0.05 | 1.1 | NM_021227 | 0 | 58505 | 1429898_at | 0 | -0.276 | -0.869 | 0 | -3.44E-02 | -1.08E-01 | Mm.300697 | 2310008M10Rik |
| 1449139_at | 0.442 | 1.003 | 3.32E-01 | 7.53E-01 | Mm.300697 | 2310008M10Rik | ||||||||||||||||||
| AA001749 | Hs.472437 | "Microtubule-associated protein, RP/EB family, member 1" | MAPRE1 | 0 | 0.14 | 2.3 | -1 | -0.16 | -3.4 | 0 | -0.08 | -1 | NM_012325 | 1 | 22919 | 1422764_at | 1 | 0.111 | 0.334 | 0 | 2.55E-01 | 7.67E-01 | Mm.143877 | Mapre1 |
| 1422765_at | 0.835 | 4.955 | 2.49E-01 | 1.48E+00 | Mm.143877 | Mapre1 | ||||||||||||||||||
| 1428819_at | 0.426 | 0.84 | 7.31E-02 | 1.44E-01 | Mm.143877 | Mapre1 | ||||||||||||||||||
| 1428820_at | -0.189 | -0.57 | -1.53E-01 | -4.60E-01 | Mm.143877 | Mapre1 | ||||||||||||||||||
| 1450740_a_at | 0.25 | 0.597 | 2.89E-01 | 6.90E-01 | Mm.143877 | Mapre1 | ||||||||||||||||||
| AA001897 | Hs.119825 | "Spectrin, alpha, erythrocytic 1 (elliptocytosis 2)" | SPTA1 | 0 | 0.07 | 0.7 | 1 | 0.21 | 4.1 | 0 | -0.13 | -1.6 | NM_003126 | 0 | 6708 | 1421277_at | 0 | -1.176 | -1.64 | 0 | -8.59E-02 | -1.20E-01 | Mm.200611 | Spna1 |
| 1421278_s_at | -1.343 | -1.699 | -1.37E-01 | -1.74E-01 | Mm.200611 | Spna1 | ||||||||||||||||||
| AA002086 | Hs.1311 | "CD1C antigen, c polypeptide" | CD1C | 0 | 0.29 | 3.4 | 0 | -0.01 | -0.1 | 0 | -0.06 | -0.7 | NM_001765 | ND | 911 | Data not found | ND | ND | ||||||
| AA002126 | Hs.127799 | Baculoviral IAP repeat-containing 3 | BIRC3 | 0 | 0.15 | 3.2 | 0 | -0.1 | -1.1 | 0 | -0.08 | -0.7 | NM_001165 | 0 | 330 | 1421392_a_at | 0 | 0.067 | 0.3 | 0 | 2.28E-01 | 1.03E+00 | Mm.2026 | Birc3 |
| 1425223_at | -0.048 | -0.315 | -2.86E-01 | -1.86E+00 | Mm.2026 | Birc3 | ||||||||||||||||||
| AA002126 | Hs.127799 | Baculoviral IAP repeat-containing 3 | BIRC3 | 0 | 0.15 | 2.9 | 0 | -0.05 | -0.6 | 0 | -0.06 | -0.4 | NM_001165 | 0 | 330 | 1421392_a_at | 0 | 0.067 | 0.3 | 0 | 2.28E-01 | 1.03E+00 | Mm.2026 | Birc3 |
| 1425223_at | -0.048 | -0.315 | -2.86E-01 | -1.86E+00 | Mm.2026 | Birc3 | ||||||||||||||||||
| AA004317 | Hs.533308 | "Protein phosphatase 2, regulatory subunit B (B56), delta isoform" | PPP2R5D | 0 | 0.07 | 1.4 | 0 | 0 | 0 | 0 | 0.01 | 0.2 | NM_006245 | 0 | 5528 | 1450560_a_at | 0 | 0.086 | 0.282 | 0 | -4.54E-01 | -1.48E+00 | Mm.295009 | Ppp2r5d |
| AA004664 | Data not found | 0 | 0.01 | 0.2 | 0 | -0.07 | -1.2 | 0 | -0.15 | -1.5 | ND | Data not found | ||||||||||||
| AA004687 | Data not found | 0 | -0.07 | -0.8 | 0 | -0.03 | -0.5 | 0 | 0.11 | 1.4 | ND | Data not found | ||||||||||||
| AA004759 | Hs.549080 | "Dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit" | DPM1 | 0 | -0.11 | -2.1 | -1 | -0.14 | -4.2 | -1 | -0.21 | -4.2 | NM_003859 | 0 | 8813 | 1420253_at | 0 | 0.174 | 0.503 | 0 | 2.98E-01 | 8.63E-01 | Mm.201322 | Adnp |
| 1423069_at | 0.085 | 0.317 | 1.06E-01 | 3.98E-01 | Mm.201322 | Adnp | ||||||||||||||||||
| 1449795_at | -0.043 | -0.289 | -3.32E-02 | -2.25E-01 | Mm.201322 | Adnp | ||||||||||||||||||
| AA004823 | Hs.517172 | Death associated transcription factor 1 | DATF1 | 0 | -0.21 | -1.9 | 0 | 0.03 | 0.4 | 0 | -0.26 | -2.8 | NM_022105 | 0 | 11083 | Data not found | ND | ND | ||||||
| AA004823 | Hs.517172 | Death associated transcription factor 1 | DATF1 | 0 | -0.09 | -1.2 | 0 | 0.05 | 0.3 | 0 | -0.05 | -0.2 | NM_022105 | 0 | 11083 | Data not found | ND | ND | ||||||
| AA004835 | Hs.153299 | Dom-3 homolog Z (C. elegans) | DOM3Z | 0 | -0.11 | -1.1 | 0 | 0.02 | 0.3 | 0 | 0.14 | 2 | NM_005510 | 0 | 1797 | 1423116_at | -1 | -0.401 | -2.51 | 0 | -1.35E-01 | -8.44E-01 | Mm.275309 | Dom3z |
| AA005153 | Hs.478125 | InaD-like (Drosophila) | INADL | 0 | -0.07 | -1 | 0 | -0.02 | -0.3 | 0 | 0 | 0 | NM_005799 | 0 | 10207 | Data not found | ND | ND | ||||||
| AA005215 | Hs.155342 | "Protein kinase C, delta" | PRKCD | 0 | -0.02 | -0.3 | 0 | 0.03 | 0.7 | 0 | 0.09 | 1.5 | NM_006254 | 0 | 5580 | 1422847_a_at | -1 | -0.087 | -0.236 | 0 | 5.58E-02 | 1.51E-01 | Mm.2314 | Prkcd |
| 1442256_at | -0.675 | -2.526 | -2.61E-01 | -9.78E-01 | Mm.2314 | Prkcd | ||||||||||||||||||
| AA005219 | Hs.148266 | Glycerol-3-phosphate dehydrogenase 2 (mitochondrial) | GPD2 | 0 | -0.19 | -0.6 | 0 | 0.09 | 1.7 | 1 | 0.23 | 3.1 | NM_000408 | 0 | 2820 | 1417434_at | 0 | -0.371 | -1.56 | -1 | -9.83E-02 | -4.13E-01 | Mm.3711 | Gpd2 |
| 1428323_at | 0.051 | 0.207 | -2.90E-01 | -1.17E+00 | Mm.3711 | Gpd2 | ||||||||||||||||||
| 1452741_s_at | -0.303 | -1.911 | -3.36E-01 | -2.12E+00 | Mm.3711 | Gpd2 | ||||||||||||||||||
| AA005219 | Hs.148266 | Glycerol-3-phosphate dehydrogenase 2 (mitochondrial) | GPD2 | 0 | 0.09 | 0.6 | 0 | 0.12 | 2.3 | 0 | 0.05 | 0.6 | NM_000408 | 0 | 2820 | 1417434_at | 0 | -0.371 | -1.56 | -1 | -9.83E-02 | -4.13E-01 | Mm.3711 | Gpd2 |
| 1428323_at | 0.051 | 0.207 | -2.90E-01 | -1.17E+00 | Mm.3711 | Gpd2 | ||||||||||||||||||
| 1452741_s_at | -0.303 | -1.911 | -3.36E-01 | -2.12E+00 | Mm.3711 | Gpd2 | ||||||||||||||||||
| AA005382 | Hs.277937 | "Granzyme K (serine protease, granzyme 3; tryptase II)" | GZMK | 1 | 0.29 | 5.3 | 0 | 0.01 | 0.1 | 0 | 0.01 | 0.1 | NM_002104 | 0 | 3003 | 1422280_at | 0 | 0.097 | 0.639 | 0 | -5.78E-02 | -3.80E-01 | Mm.56993 | Gzmk |
| AA007395 | Hs.1219 | "Alcohol dehydrogenase 4 (class II), pi polypeptide" | ADH4 | 0 | 0.27 | 1.2 |